• Sexual reproduction is the main reproductive strategy of the vast majority of Eukaryotic species. This strategy requires the development of a highly specialized cell lineage, the germ line, which is the truly immortal cell population in higher Eukaryotes. In fact, it is precisely the germ line that unites the past, present and future of each […]

  • Drosophila melanogaster embryonic development starts with thirteen nuclear divisions without cytokinesis (syncytial blastoderm), being these divisions among the fastest known for any animal embryonic system. Drosophila syncytial blastoderm relies on maternally encoded gene products, loaded into the egg during oogenesis. After fertilization, and as nuclei enter interphase 14, there is a maternal to zygotic transition […]

  • N-terminal acetylation is catalyzed by a highly conserved family of N-terminal acetyltransferases (NATs). NATs activity is mostly mediated by five distinct but highly conserved complexes (NatA to NatE) bearing distinct subunits and having different substrate specificities. Additionally, we recently identified NatF, a higher eukaryote-specific NAT complex whose enzymatic activity was responsible for a significant shift […]